The CP501 arrives when you didn't respond to your CP14. The IRS is telling you: we sent this once, you didn't act, and we're not going away. The balance has grown since the CP14 — failure-to-pay penalties and daily interest have been compounding the entire time.
The tone is more urgent than the CP14, but you're still in the pre-enforcement phase. No levy has been issued. No garnishment has been authorized. The IRS is still in the automated notice sequence, which means a professional response can still halt the escalation entirely.
What the CP501 does signal is that your window to act cheaply is closing. Every week without a resolution adds to the balance and eliminates programs that require timely filing. First-time abatement, for instance, must be requested proactively — waiting until enforcement begins makes it significantly harder to obtain.